| Application: | EnzymeInhibition |
| MolecularWeight: | 100-500 |
| ResearchArea: | HistoneAcetylation |
| Solubility: | DMSO,Ethanol,Other |
| 100%Guarantee: | 6months |
AlternativeNames
TSA,[R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptADIenamide
Description
TrichostatinAisapotentandnon-competitivereversIBLeinhibitorofhistonedeacetylases(HDAC)withaKiof3.4nM.InHeLacells,TSAblockedcellcycleprogressionatG1andinduceda12-foldincreaseinintracellularlevelsofgelsolin.IncellslatentlyinfectedwithHIV-1,TSAinducedthetranscriptionalactivationoftheHIV-1promoter,whichresultedinamarkedincreaseinvirusproduction.InNIH3T3cells,TSAinducedreversionofoncogenicras-transformedcellstoanormalmorphology.InJurkatcells,TSAinhibitedIL-2geneexpressionanddisplayedimmunosuppressiveactivityinamousemodel.InducesincreasedacetylationofGATA4,acardiac-specifictranscriptionfactorandincreasescardiacmusclecelldifferentiation.Innormalratfibroblasts,inducedFriendcelldifferentiationandinhibitedtheG1andG2phasesofthecellcycle.TrichostatinAisausefultoolforinductionofhyperacetylationofcellularhistonesandforfurtherelucidationoftheirroleingeneexpression.
CASNumber
58880-19-6
ChemicalFormula
C17H22N2O3
MolecularWeight
302.4
Size
1mg
Purity
99%
Solubility
SolubleinDMSO,DMFandethanol
StorageTemp
-20°C
