| Application: | EnzymeInhibition |
| MolecularWeight: | 100-500 |
| ResearchArea: | HistoneAcetylation |
| Solubility: | DMSO,Ethanol,Other,Water |
| 100%Guarantee: | 6months |
AlternativeNames
Camboginol
Description
GarcinolisapolyisoprenylatedbenzophenonederivativefromtherindofGarciniaindicafruitandisapotentinhibitorofhistoneacetyltransferasesp300(IC50=~7µm)andPCAF(IC50=~5µm)bothinvitroandinvivo.p300,alsoknownasE1Abindingproteinp300,regulatescellgrowthanddivisionthroughinteractingwithnumeroustranscriptionfactors,andthep53associatedtrancriptionalcoactivatorPCAF(P300/CBP-associatedfactor)playsadirectroleintranscriptionalregulation.ReportsshowthatGarcinolrepressesthep300-mediatedacetylationofp53invivo,promotesapoptosisthroughcaspase-3activationandpredominantlydown-regulatesglobalgeneexpressioninHeLacells.ResearchersfoundthatGarcinolexhibitsdose-dependentcancercell-specificgrowthinhibitioninER-positiveMCF-7andER-negativeMDA-MB-231breastcancercells.AdditionalresearchshowsthatGarcinolexhibitsanti-carcinogenicandanti-inflammatorypropertiesthroughselectivelysuppressingProstaglandinE2synthesisand5-lipoxygenaseproductformation.
CASNumber
78824-30-3
ChemicalFormula
C38H50O6
MolecularWeight
602.8
Size
10mg
Purity
95%
Solubility
SolubleinDMSO(25mg/ml),Ethanol(25mg/ml),DMF(25mg/ml),Water(nil)
StorageTemp
-20°C
