| Application: | EnzymeInhibition |
| MolecularWeight: | 100-500 |
| ResearchArea: | HistoneAcetylation |
| Solubility: | DMSO,Ethanol,Other,Water |
| 100%Guarantee: | 6months |
AlternativeNames
(E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptADIene-3,5-dioneDiferuloylmethaneDiferulylmethane
Description
Curcuminisayellow-orangedyeobtainedfromtumeric,thepowderedrootofCurcumalonga;itisemployedinthepreparationofcurcumapaper,thedetectionofboron,andpossessesavastnumberofBIOLOGicaltargets.CurcuminhasbeenshowntoinhibitNF-κB(possIBLythruinhibitionofJNK;IC50=10μM),blocksamyloidpeptideinducedexpressionof:TNF-α,IL-1β,MCP-1,IL-8,andCCR5,regulatesNOS2,inhibitsIgEandAg-induceddegranulationofmastcells,inhibits5-LO(5-lipoxygenase;IC50=8μM),Cox-2(cyclooxygenase-2;IC50=52μM),theCOP9signalosomekinase(IC50=10µM),andp300/CBP.ThiswiderangeofactivitiesmakesCurcuminanextremelyusefultoolfordevelopingnovelanalogousmoleculesanddiscoveringnewusesforthisnaturallyoccurringcompound.
CASNumber
458-37-7
ChemicalFormula
C21H20O6
MolecularWeight
368.38
Size
1g
Purity
≥95%
Solubility
Solubleinwater,ethanol(10mg/ml),DMSO(25mg/ml)andaceticacid
StorageTemp
-20°C
