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Epigentek/AGER Polyclonal Antibody, HRP Conjugated/A52167-100/100 µg
| Application: | ELISA |
| AreasofResearch: | Immunology&Inflammation,SignalTransduction |
| Clonality: | Polyclonal |
| Conjugate: | HRP |
| Host: | Rabbit |
| Isotype: | IgG |
| Purification: | >95%,ProteinGPurified |
| Reactivity: | Human |
| 100%Guarantee: | 6months |
Background
Mediatesinteractionsofadvancedglycosylationendproducts(AGE).Thesearenonenzymaticallyglycosylatedproteinswhichaccumulateinvasculartissueinagingandatanacceleratedrateindiabetes.Actsasamediatorofbothacuteandchronicvascularinflammationinconditionssuchasatherosclerosisandinparticularasacomplicationofdiabetes.AGE/RAGEsignalingplaysanimportantroleinregulatingtheproduction/expressionofTNF-alpha,oxidativestress,andendothelialdysfunctionintype2diabetes.InteractionwithS100A12onendothelium,mononuclearphagocytes,andlymphocytestriggerscellularactivation,withgenerationofkeyproinflammatorymediators.InteractionwithS100BaftermyocardialinfarctionmayplayaroleinmyocyteapoptosisbyactivatingERK1/2andp53/TP53signalingBysimilarity.Receptorforamyloidbetapeptide.Contributestothetranslocationofamyloid-betapeptide(ABPP)acrossthecellmembranefromtheextracellulartotheintracellularspaceincorticalneurons.ABPP-initiatedRAGEsignaling,especiallystimulationofp38mitogen-activatedproteinkinase(MAPK),hasthecapacitytodriveatransportsystemdeliveringABPPasacomplexwithRAGEtotheintraneuronalspace.
Description
AGERPolyclonalAntibody,HRPConjugated.HRP.Raisedin:Rabbit.
Formulation
Liquid.0.03%Proclin300,50%Glycerol,0.01MPBS,PH7.4.
Specificity
Human
Isotype
IgG
UniprotID
Q15109
Purification
>95%,ProteinGpurified
Immunogen
RecombinanthumanAdvancedglycosylationendproduct-specificreceptorprotein(23-342AA)
Storage
Shippedat4°C.Upondeliveryaliquotandstoreat-20°C(short-term)or-80°C(long-term).Avoidrepeatedfreeze.
AlternativeNames
Receptorforadvancedglycosylationendproducts,AGER,RAGE
Application
ELISA
VCU0006
