Background
Atypicalchemokinereceptorthatcontrolschemokinelevelsandlocalizationviahigh-affinitychemokinebindingthatisuncoupledfromclassicligand-drivensignaltransductioncascades,resultinginsteadinchemokinesequestration,degradation,ortranscytosis.Alsoknownasinterceptor(internalizingreceptor)orchemokine-scavengingreceptororchemokinedecoyreceptor.Hasapromiscuouschemokine-bindingprofile,interactingwithinflammatorychemokinesofboththeCXCandtheCCsubfamiliesbutnotwithhomeostaticchemokines.ActsasareceptorforchemokinesincludingCCL2,CCL5,CCL7,CCL11,CCL13,CCL14,CCL17,CXCL5,CXCL6,IL8/CXCL8,CXCL11,GRO,RANTES,MCP-1,TARCandalsoforthemalariaparasitesP.vivaxandP.knowlesi.MayregulatechemokinebioavailABIlityand,consequently,leukocyterecruitmentthroughtwodistinctmechanisms:whenexpressedinendothelialcells,itsustainstheabluminaltoluminaltranscytosisoftissue-derivedchemokinesandtheirsubsequentpresentationtocirculatingleukocytes;whenexpressedinerythrocytes,servesasbloodreservoirofcognatechemokinesbutalsoasachemokinesink,bufferingpotentialsurgesinplasmachemokinelevels.

Description
ACKR1PolyclonalAntibody.Unconjugated.Raisedin:Rabbit.

Formulation
Liquid.0.03%Proclin300,50%Glycerol,0.01MPBS,PH7.4.

Specificity
Human,Mouse

Isotype
IgG

UniprotID
Q16570

Purification
>95%,ProteinGpurified

Immunogen
RecombinanthumanAtypicalchemokinereceptor1protein(1-63AA)

Storage
Shippedat4°C.Upondeliveryaliquotandstoreat-20°C(short-term)or-80°C(long-term).Avoidrepeatedfreeze.

AlternativeNames
Atypicalchemokinereceptor1,Duffyantigen/chemokinereceptor,GlycoproteinD,Plasmodiumvivaxreceptor,ACKR1,DARC,FY,GPD

Application
ELISA,WB,IF;Recommendeddilution:WB:1:1000-1:5000,IF:1:50-1:200

VCU0006