| Application: | ELISA |
| AreasofResearch: | SignalTransduction |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Host: | Rabbit |
| Isotype: | IgG |
| Purification: | >95%,ProteinGPurified |
| Reactivity: | Human |
| 100%Guarantee: | 6months |
Background
Transmembraneserine/threoninekinaseactivintype-1receptorforminganactivinreceptorcomplexwithactivinreceptortype-2(ACVR2AorACVR2B).Transducestheactivinsignalfromthecellsurfacetothecytoplasmandisthusregulatingamanyphysiologicalandpathologicalprocessesincludingneuronaldifferentiationandneuronalsurvival,hairfollicledevelopmentandcycling,FSHproductionbythepituitarygland,woundhealing,extracellularmatrixproduction,immunosuppressionandcarcinogenesis.Activinisalsothoughttohaveaparacrineorautocrineroleinfolliculardevelopmentintheovary.Withinthereceptorcomplex,type-2receptors(ACVR2Aand/orACVR2B)actasaprimaryactivinreceptorswhereasthetype-1receptorslikeACVR1Bactasdownstreamtransducersofactivinsignals.Activinbindstotype-2receptorattheplasmamembraneandactivatesitsserine-threoninekinase.Theactivatedreceptortype-2thenphosphorylatesandactivatesthetype-1receptorsuchasACVR1B.Onceactivated,thetype-1receptorbindsandphosphorylatestheSMADproteinsSMAD2andSMAD3,onserineresiduesoftheC-terminaltail.Soonaftertheirassociationwiththeactivinreceptorandsubsequentphosphorylation,SMAD2andSMAD3arereleasedintothecytoplasmwheretheyinteractwiththecommonpartnerSMAD4.ThisSMADcomplextranslocatesintothenucleuswhereitmediatesactivin-inducedtranscription.InhibitorySMAD7,whichisrecruitedtoACVR1BthroughFKBP1A,canpreventtheassociationofSMAD2andSMAD3withtheactivinreceptorcomplex,therebyblockingtheactivinsignal.Activinsignaltransductionisalsoantagonizedbythebindingtothereceptorofinhibin-BviatheIGSF1inhibincoreceptor.ACVR1BalsophosphorylatesTDP2.
Description
ACVR1BPolyclonalAntibody.Unconjugated.Raisedin:Rabbit.
Formulation
Liquid.0.03%Proclin300,50%Glycerol,0.01MPBS,PH7.4.
Specificity
Human
Isotype
IgG
UniprotID
P36896
Purification
>95%,ProteinGpurified
Immunogen
RecombinanthumanActivinreceptortype-1Bprotein(150-300AA)
Storage
Shippedat4°C.Upondeliveryaliquotandstoreat-20°C(short-term)or-80°C(long-term).Avoidrepeatedfreeze.
AlternativeNames
Activinreceptortype-1B(EC:2.7.11.30),ACVR1B,ACVRLK4,ALK4,ActivinreceptortypeIB,ACTR-IB,Activinreceptor-likekinase4,ALK-4,Serine/threonine-proteinkinasereceptorR2,SKR2
Application
ELISA
VCU0006
