| Application: | ELISA |
| AreasofResearch: | Apoptosis&CellDeath,CellCycle,TranscriptionFactors |
| Clonality: | Polyclonal |
| Conjugate: | HRP |
| Host: | Rabbit |
| Isotype: | IgG |
| Purification: | >95%,ProteinGPurified |
| Reactivity: | Human |
| 100%Guarantee: | 6months |
Background
MayfunctionasageneralinhibitorofthehistonedeacetylaseHDAC1.BindingtothepocketregionofRB1maydisplaceHDAC1fromRB1/E2Fcomplexes,leADIngtoactivationofE2Ftargetgenesandcellcycleprogression.Conversely,displacementofHDAC1fromSP1boundtotheCDKN1ApromoterleadstoincreasedexpressionofthisCDKinhibitorandblockscellcycleprogression.AlsoantagonizesPAWRmediatedinductionofaberrantamyloidpeptideproductioninAlzheimerdisease(presenileandseniledementia),althoughthemolecularbasisforthisphenomenonhasnotbeendescribedtodate.
Description
AATFPolyclonalAntibody,HRPConjugated.HRP.Raisedin:Rabbit.
Formulation
Liquid.0.03%Proclin300,50%Glycerol,0.01MPBS,PH7.4.
Specificity
Human
Isotype
IgG
UniprotID
Q9NY61
Purification
>95%,ProteinGpurified
Immunogen
RecombinanthumanProteinAATFprotein(6-294AA)
Storage
Shippedat4°C.Upondeliveryaliquotandstoreat-20°C(short-term)or-80°C(long-term).Avoidrepeatedfreeze.
Application
ELISA
VCU0006
