| Application: | ELISA |
| Areas of Research: | Apoptosis & Cell Death, Cell Cycle, Transcription Factors |
| Clonality: | Polyclonal |
| Conjugate: | Biotin |
| Host: | Rabbit |
| Isotype: | IgG |
| Purification: | >95%, Protein G Purified |
| Reactivity: | Human |
| 100% Guarantee: | 6 months |
Background
May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.
Description
AATF Polyclonal Antibody, Biotin Conjugated. Biotin. Raised in: Rabbit.
Formulation
Liquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.
Specificity
Human
Isotype
IgG
Uniprot ID
Q9NY61
Purification
>95%, Protein G purified
Immunogen
Recombinant human Protein AATF protein (6-294AA)
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Application
ELISA
VCU0006
